TGF-beta is a pivotal cytokine which is involved in a variety of cellular functions. Our group has been focused on the signaling pathways mediated by TGF-beta superfamily cytokines regarding cancer progression and anti-inflammation during the past decade. Our current research focuses on the identification of novel mechanism of TGF-beta or BMP-mediated tumorigenesis and metastasis. In addition, we are also doing the studies about how specific signaling pathways in the inflammation and cancer biology are regulated by ubiquitination and deubiquitinating mechanism. Through these diverse approaches, the final goal in our group is to understand the molecular mechanisms regarding cancer and inflammation and subsequently to identify therapeutic target proteins to treat cancer and inflammation.
Education
(PhD) 1998 Seoul National University, Korea
Experience
2007 Mar - Present Professor, Department of Biological Sciences, Sungkyunkwan University
2003 Mar - 2007 Feb Assistant Professor, Inha University College of Medicine
2001 May - 2003 Feb Senior Principle Investigator, National Cancer Center, Research Institute
1998 Aug - 2001 April National Cancer Institute, National Institute of Health, USA
2015 Sep - Present Chairman, Department of Biological Sciences
(2023)
Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
METABOLISM-CLINICAL AND EXPERIMENTAL.
151,
155746
(2023)
<i>Peli3</i> ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.
EXPERIMENTAL AND MOLECULAR MEDICINE.
55,
6
(2023)
Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors.
CELL DEATH & DISEASE.
14,
2
(2022)
SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS-and p38 MAPK-Dependent Pathways.
IMMUNE NETWORK.
22,
4
(2022)
Structural mechanism for regulation of Rab7 by site-specific monoubiquitination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.
194,
-
(2021)
Serum amyloid A promotes emphysema by triggering the reciprocal activation of neutrophils and ILC3s.
CLINICAL AND TRANSLATIONAL MEDICINE.
11,
12
(2021)
Metastasis Risk Assessment Using BAG2 Expression by Cancer-Associated Fibroblast and Tumor Cells in Patients with Breast Cancer.
CANCERS.
13,
18
(2020)
Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages.
BMB REPORTS.
53,
12
(2020)
TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES.
79,
12
(2020)
The Deubiquitinating Enzyme USP20 Regulates the TNF alpha-Induced NF-kappa B Signaling Pathway through Stabilization of p62.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
9
(2020)
Inhibition of TGF-beta signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
SCIENTIFIC REPORTS.
10,
1
(2019)
The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
EBIOMEDICINE.
49,
-
(2019)
High A20 expression negatively impacts survival in patients with breast cancer.
PLOS ONE.
14,
8
(2019)
A novel SMAD6 variant in a patient with severely calcified bicuspid aortic valve and thoracic aortic aneurysm.
MOLECULAR GENETICS & GENOMIC MEDICINE.
7,
5
(2019)
A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells.
STEM CELLS.
37,
3
(2018)
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
EMBO REPORTS.
19,
4
(2017)
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
CELL REPORTS.
21,
10
(2017)
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
NATURE CELL BIOLOGY.
19,
10
(2017)
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion.
ELIFE.
6,
Patent/Intellectual Property
BAG2 항체를 이용한 암 진단용 조성물 및 이를 이용한 방법.
10-2019-0016347.
20201027.
KOREA, REPUBLIC OF
케톤 펩타이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학적 조성물.
10-2014-0148199.
20161024.
KOREA, REPUBLIC OF
펩타이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학적 조성물.
10-2014-0148198.
20160229.
KOREA, REPUBLIC OF
스매드 6번(Ｓｍａｄ６)으로부터 유래된 펩타이드를 유효성분으로 포함하는 패혈증 또는 패혈성 쇼크의 치료용 조성물.
10-2011-0144262.
20140129.
KOREA, REPUBLIC OF
Conference Paper
(2023)
Adipocyte-specific loss of the ubiquitin editing enzyme A20 regulates energy homeostasis through altered lipid metabolism in diet-induced obese mice..
2023 International Conference KSMCB.
KOREA, REPUBLIC OF
(2023)
SERTADl promotes inflammasome activation by interfering with the interaction between NLRP3 and CULl E3ligase: Implication of SERTADl in autoimmune disease.
2023 International Conference KSMCB.
KOREA, REPUBLIC OF
(2023)
Peli3 ablation ameliorates acetaminophen -induced liver injury through inhibition of GSK3 ß phosphorylation and mitochondrial translocation.
KSBMB International Conference 2023.
KOREA, REPUBLIC OF
(2022)
Ablation of Pellino3 protein attenuates bleomycin-induced idiopathic pulmonary fibrosis through regulating monocyte recruitment.
2022 international conference of Korean Society for Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2020)
The deubiquitinating enzyme USP20 regulates TNFa-induced NF-kB signaling pathway through the stabilization of p62.
2020 International Conference: Korean Society for Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2019)
The deubiquitinase PSMD14 enhances colorectal cancer tumorigenesis and cancer stemness by stabilizing BMP type I receptor ALK2/ACVR1a.
2019 International Conference Korean Society for Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2019)
Novel molecular mechanisms of cancer metastasis and anti-inflammation by TGF-beta signaling pathway.
한국분자세포생물학회 제30회 동계학술대회.
KOREA, REPUBLIC OF
(2018)
The deubiquitinating enzyme USP20 is required for autophagy initiation through the stabilization of ULK1.
Cold Spring Harbor Meeting; Mechanisms & Models of Cancer.
UNITED STATES
(2018)
Breast cancer metastasis and TGF-beta-induced EMT by Snail1 multimonoubiquitination.
대한암예방학회 2016 오색심포지엄.
KOREA, REPUBLIC OF
(2018)
A20 ubiquitin editing enzyme in breast cancer metastasis and EMT.
한국분자세포생물학회 2018 PMD Conference.
KOREA, REPUBLIC OF
(2017)
TGF-beta-induced EMT and metastasis of aggressive basal-like breast cancers.
The 1st Inter-academy cancer symposium Keio-NCC GCSP Communications in Cancer Science.
KOREA, REPUBLIC OF
(2017)
TNFAIP3 is involved in the metastasis of highly aggressive breast cancers through modulating Snail1.
The 76th Annual Meeting of the Japanese Cancer Association.
JAPAN
(2017)
A novel pathway of EMT and metastasis in highly aggressive breast cancers.
24th Asia Pacific Cancer Conference.
KOREA, REPUBLIC OF
(2017)
Smad4 determines mesenchymal steml cell's fate in adip-osteo lineage by TAZ retention in the nucleus.
KSBMB International Conference 2017.
KOREA, REPUBLIC OF
(2017)
Selection of Smad2 for TGF-beta to suppress dendritic cells by STAT3/c-Ski-induced repression of Smad3.
The 110th Annual Meeting of American Association for Cancer Research.
UNITED STATES
(2016)
Selection of Smad2 for TGF-beta to suppress dendritic cells by STAT3/c-Ski-induced repression of Smad3.
The 45th Annual Meeting of The Japanese Society for Immunology.
JAPAN
(2016)
Deubiquitinating enzyme USP50 is a critical regulator for NLRP3 inflammasome activation.
16th International Congress of Immunology.
AUSTRALIA
(2015)
Distinct role of PSMD14/POH1 in the regulation of BMP signaling pathway in human colorectal cancer cells..
The 27th International Conference of the Korean Society for Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2015)
Pellino3 exacerbates acetaminophen-induced hepatotoxicity by increasing necrotic cell death..
The 27th International Conference of the Korean Society for Molecular and Cellular Biology.
KOREA, REPUBLIC OF
(2015)
A20 facilitates TGF-beta-induced EMT through stabilizing Snail1..
2nd international symposium on protein modifications in pathogenic dysregulation of signaling.
JAPAN
